17 β-Estradiol promotes vascular endothelial growth factor expression via the Wnt/β-catenin pathway during the pathogenesis of endometriosis
نویسندگان
چکیده
منابع مشابه
P-182: The Role of Vascular Endothelial Growth Factor Gene Expression in Patients with the History of Endometriosis
Background: Endometriosis is the presence of endometrium- like tissue in sites outside the uterine cavity, primarily on the pelvic peritoneum and ovaries. Ectopic endometrium for replacement and growth require to blood supply. Vascular endothelial growth factor (VEGF) is one of the most important intermediate of locality angiogenesis that product by monocytes and macrophages. This study evaluat...
متن کاملP-171: Expression of Vascular Endothelial Growth Factor Receptors In Endometriosis
Background: Endometriosis is a disease which is defined by the growth of endometrium-like tissue outside of the uterine cavity. Literatures show that VEGF by interaction with their receptors, Flt-1 (Fms-like tyrosine kinase-1 or VEGFR-1) and Flk-1/KDR (fetal liver kinase/ kinase-insert domain receptor or VEGFR-2) is related to pathogenesis of endometriosis. The purpose of this study was to eval...
متن کاملThe Association Analysis of Vascular Endothelial Growth Factor -2549 Insertion/Deletion Variant and Endometriosis Risk
Endometriosis is a debilitating disorder, defined as the presence of endometrial gland and stroma outside of the uterus. It may affect angiogenesis and vascular endothelial growth factor (VEGF) is one of the angiogenic factors that plays an important role in both physiological and pathological angiogenesis. The present study aimed to evaluate the association of VEGF -2549 insertion/deletion (I/...
متن کاملThe Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/β-Catenin Signaling
Blood vessel stability is essential for embryonic development; in the adult, many diseases are associated with loss of vascular integrity. The ETS transcription factor ERG drives expression of VE-cadherin and controls junctional integrity. We show that constitutive endothelial deletion of ERG (Erg(cEC-KO)) in mice causes embryonic lethality with vascular defects. Inducible endothelial deletion ...
متن کاملEffect of matrine against breast cancer by downregulating the vascular endothelial growth factor via the Wnt/β-catenin pathway
The aim of the present study was to investigate the effect of matrine on breast cancer and its underlying mechanism. Matrine is a major component of Sophora flavescens, exhibited antitumor activity in a number of neoplasms, including breast cancer. The present study revealed that matrine inhibited cell viability and induced apoptosis in 4T1 and MCF-7 cells in a dose- and time-dependent manner i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2016
ISSN: 1360-9947,1460-2407
DOI: 10.1093/molehr/gaw025